A Fluorogenic Histone Deacetylase Assay Well Suited for High-Throughput Activity Screening
نویسندگان
چکیده
منابع مشابه
Identification of novel small-molecule histone deacetylase inhibitors by medium-throughput screening using a fluorigenic assay.
HDACs (histone deacetylases) are considered to be among the most important enzymes that regulate gene expression in eukaryotic cells. In general, increased levels of histone acetylation are associated with increased transcriptional activity, whereas decreased levels are linked to repression of gene expression. HDACs associate with a number of cellular oncogenes and tumour-suppressor genes, lead...
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ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 2003
ISSN: 1074-5521
DOI: 10.1016/s1074-5521(02)00305-8